Florian Weber

Curriculum vitae

• Since 11/2015 Doctoral Student, Friedrich-Schiller-University, Jena, Germany, Department of Pharmaceutical Technology, Phospholipids in Drug Development
• 10/2015 Licensure as Pharmacist in Germany
• 10/2014 Second State exam in Pharmacy, Martin-Luther-University Halle, Germany

Thesis:

Development of targeted lipid-based tools for non-invasive molecular diagnostic of hepatic fibrosis

Abstract:

Fibrosis is a pathological reaction that could arise in various tissues and organs as a response to acute or chronic injury. If it remains untreated, this process will finally lead to organ malfunction and death. Particularly, liver fibrosis is responsible for a high morbidity because of the development of cirrhosis and hepatocellular carcinoma. Moreover, the major issue is related to the diagnosis of liver fibrosis. A definite diagnosis can only be achieved by liver biopsy, an invasive methodology that often implicates high risk for complications and misjudgement. Due to the high prevalence and mortality of hepatic fibrosis and the necessity of repetitive evaluation of disease progression, emphasis will be placed on the development and physicochemical characterization as well as in vitro cell culture testing of targeted liposomes for non-invasive diagnostic molecular imaging for an early diagnosis and comprehensive prognosis to improve management strategies of this chronic fibro-proliferative disease.

Lipoid GmbH is gratefully acknowledged for the endowment to this project and to the Friedrich-Schiller-University of Jena