Natural and Synthetic Polymers as Drug Delivery Systems

• Formulation and physicochemical characterization of micro- and nanoparticles, nanofibers and nanocrystals as delivery systems for innovative drugs (DNA/RNA, proteins, peptides, natural drugs, etc.)
• Strategies of cellular drug targeting
• Applications in pharmacy, medicine and cosmetics with a focus on inflammation, cancer, aging
• Focus on the use of natural polymers and natural drugs
• Investigation of drug delivery properties on biological barriers
• Qualitative and quantitative analytics of drugs in biological and non-biological matrices

Recent activities:

• Member of the Jena Center for Soft Matter
• SFB Polytarget
• DFG „Ex-vivo Untersuchung des therap. Potenzials von Nanopart. -basierten inhalativen Antibiotika bei Cystischer Fibrose"

Selected papers for further information:

• Klinger-Strobel M, Ernst J, Lautenschläger C, Pletz MW, Fischer D, Makarewicz O (2016). A blue fluorescent labeling technique utilizing micro- and nanoparticles for tracking in LIVE/DEAD® stained pathogenic biofilms of Staphylococcus aureus and Burkholderia cepacia. Int J Nanomedicine. Feb 2016;11:575-83
• Ochrimenko S, Vollrath A, Tauhardt L, Kempe K, Schubert S, Schubert US, Fischer D (2014). Dextran-graft-linear poly(ethylene imine)s for gene delivery: importance of the linking strategy.. Carbohydr Polym. Nov 2014; 113:597-606.
• Lautenschläger C, Schmidt C, Lehr CM, Fischer D, Stallmach A. (2013). PEG-functionalized microparticles selectively target inflamed mucosa in inflammatory bowel disease. Eur J Pharm Biopharm. Nov 2013; 85(3 Pt A):578-86