Bacterial Nanocellulose as Drug Delivery System

The natural hydropolymer bacterial nanocellulose (BNC) is an innovative biomaterial, produced by strains of Gram-negative bacteria Komagataeibacter xylinus. Although the chemical formula is identical to plant cellulose, the material favours totally different, but outstanding material characteristics due to the three-dimensional network of nano-sized fibres. The interest in BNC as drug delivery system dramatically increased during the last years, as the nano-sized 3D-network of BNC is expected to hold a large amount of drug molecules due to its large surface area.

Activities:

  • Development of tailored loading and release strategies for drugs (loading efficiency, speed of loading, drug location, release profiles)
  • Custom-design as immediate and sustained drug release system for ready-to-use and bedside applications
  • Application as a high potential drug delivery system in pharmacy, medicine and cosmetics (e.g. antiseptics, antibiotics, natural drugs, proteins, peptide, DNA/RNA, etc.)

Recent activities:
InflammAging

Selected papers for further information:

  • Pötzinger Y, Rabel M, Ahrem H, Thamm J, Klemm D, Fischer D (2018) Polyelectrolyte layer assembly of bacterial nanocellulose whiskers with plasmid DNA as biocompatible non-viral gene delivery system. Cellulose, 3/2018
  • Pötzinger Y, Kralisch D, Fischer D (2017) Bacterial nanocellulose: the future of controlles drug delivery? Ther. Deliv. 8 (9), 753-761
  • Alkhatib Y, Dewaldt M, Moritz S, Nitzsche R, Kralisch D, Fischer D (2017) Controlled extended octenidine release from a bacterial nanocellulose/Poloxamer hybrid system. Eur J Pharm Biopharm. 112, 164-176
  • Müller A, Zink M, Hessler N, Wesarg F, Müller FA, Kralisch D, Fischer D (2014) Bacterial nanocellulose with a shape-memory effect as potential drug delivery system. RSC Adv. 4, 57173-57184
  • Moritz S, Wiegand C, Wesarg F, Hessler N, Müller FA, Kralisch D, Hipler UC, Fischer D (2014) Active wound dressings based on bacterial nanocellulose as drug delivery system for octenidine. Int J Pharm. 471(1-2), 45-55